I found that when I connected my iPad to my iMac for syncing after installing Lion and the new iTunes 10.4 64-bit that iTunes no longer opened automatically to begin the sync. It always had in Snow Leopard. When I checked in System Preference, Users & Groups, Login Items, the iTuneHelper.app had a yellow triangle on the right indicating that the program was not being. There were a couple of others listed from previously uninstalled applications. In checking around I found that iTunesHelper.app could be found by right clicking on iTunes in Applications and clicking on Show Contents. The information stated that iTunesHelper would be found in iTunesHelper would be found in ShowContents Applications/iTunes/Contents/Resources and could be dragged into the Login Window to create the start at login. I however located it Lion in Show Contents Applications/iTunes/Contents/MacOS instead. it was not in the other folder. I dragged it from there to the Login Window and now iTunes starts as in should when connecting a device.