Perhaps it's just me, but I never understood people who used 4K (or higher?) resolution monitors, then either run their OS at lower resolution, or used some type magnification mode or something whatever they are called.
Just get a lower resolution monitor, or a larger monitor! You can't see it, why do you pretend you can?
Not talking to you, just people who do this

and how it annoys me a bit, while it is clearly none of my business.
From 2015 I had a 40 inch 4K monitor and I found it good for that resolution. Eventually though I got tired of big screens and packed both it and a 1080 40 inch TV which I used as monitor. Now both the monitor and the TV are inside their original packaging doing nothing. I replaced them with a 27" BenQ monitor (1440p) and I am fine with that.
Don't get me wrong, having such a huge screen has some huge advantages, to the point I am tempted to take them out again as I am typing this, but I just can't stand of the huge blackness when one or both of them are off in front of me. It depresses me. I am weird, I know.
Now if the panels could be another color while they were off...yeah good luck with that.
So, to finally answer the original question, I have good eyesight and while I never connected my mini to my 4K monitor as it couldn't handle it at 60hz, having used that 40inch 4K as a monitor (PC) at normal distance ie touchable, I would say I wouldn't go for anything smaller for that resolution. But that's just me.