Sigh, I really wish there was official word from Apple on whether or not it's safe to update or install MacOS High Sierra on iMac's with fusion drives.
Try this, from MacRumors:
Apple's Craig Federighi Confirms APFS Coming to Fusion Drives in a ...
Apple ran into issues with APFS on Fusion during early beta testing, and stopped converting Fusion Drives (and mechanical HDDs) to APFS for those who joined the test afterwards. Therefore, there were many rounds of testing High Sierra on HFS+-formatted Fusion Drives. They made public statements that APFS on Fusion would return in a future release (see above). So far, it hasn't returned (I just installed the first public beta of 10.13.3 - still no APFS).
The purpose of beta testing is to make the public release safe for the public. Whether that means fixing bugs, or withholding proposed features that are not ready for release doesn't matter. The ultimate goal is a public release that works; no warnings required.
Are you looking for a statement from Apple that High Sierra is "safe?" For legal reasons, they wouldn't make such an explicit statement. You have to infer that.
https://support.apple.com/HT201475 "Can Your Mac Use High Sierra?" If it was not safe, it would say something like, "**Except models with Fusion Drive."
It does not.
What does Apple do to ensure your Fusion Drive's safety? If the installer app encounters an APFS-formatted Fusion Drive, it gracefully ends the installation and generates an error message, little different than if you were trying to install High Sierra onto a Mac running Snow Leopard or Lion. It will only install if your Fusion Drive is formatted HFS+,
and it does not convert those drives to APFS.
Bad things can still happen if you install, regardless of what kind of drive you're installing to. That's why that support article also says,
Before upgrading, it's a good idea to
back up your Mac.
I ran my Fusion Drive on APFS throughout the beta test. At the end of Beta, Apple announced that those of us who were using APFS on our Fusion Drives would have to erase and reformat our Fusion Drives to HFS+ before we could install the public release.
In other words, I and other testers with APFS-formatted Fusion drives spent many hours on a backup/erase/reformat/reinstall/restore from backup because Apple made the High Sierra public release "safe" for Fusion Drives. Oh, the sacrifices beta testers make for the sake of the general public!