Issue with Darwine/X11?

I am trying to run Darwine 0.9.27 on my Mac (OSX 10.5.6) for emulation purposes, however it does not work. I downloaded X11 2.3.2.1 from the Xquartz project to make sure I was up to date with X11, however that did not solve the problem.

For example, here is the error I get when I try and run Knytt, a compact, free Windows game:

err:module:attach_process_dlls "gdi32.dll" failed to initialize, aborting
err:module:LdrInitializeThunk Main exe initialization for L"Z:\\Users\\Banjaloupe\\Games\\Knytt\\Knytt.exe" failed, status c0000005

I think the problem is with X11, since I also cannot run GIMPshop, which I know needs X11. However, I have no experience at all using X11 in the first place, which is why I am quite stumped. Of course, the real issue could be with Darwine, or some other incompatibility I'm missing.

Thanks for your help!