Huh. I'm nowhere near an expert on the MacOS's memory allocation system, but that second screenshot does look weird. You'd kind of expect RSIZE (which is, I assume, what "werkelijk geheugen" translates to) to sum up to roughly the total allocated RAM, or at least in the ballpark. I tested on my system, and the sum of that column was somewhat less than the used total shown at the bottom of the window (a quick bit of reading didn't tell me why this is, but maybe someone more knowledgeable will chime in), but it was within maybe 15%.
The OP's system has less regular apps running than mine, and the RSIZE numbers all look totally reasonable (Safari is a little high, but not unreasonable), and it looks like it should only total to maybe a gig or so, yet it's showing 3.7GB in use. There's obviously something that isn't counted in that column eating up a lot of RAM, but I'm not seeing what it could be.
Trying a restart would probably be the first thing I'd do, but I'd also be curious as to what's going on--anybody out there who's an expert in UNIX RAM allocation want to inform us or point to a tutorial that explains it?