I'm one of those with a hard on for updates. Mostly because I like to test things and I can always roll back. Well, almost always. Anyway, in the case of iTunes and iPhone/iPad, I have learned that waiting for the DevTeam or Chronic DevTeam to give their blessing is prudent - if you want to update to the latest iOS version and maintain your jailbreak. That being said, if you want to update to iOS 4.2, you'll probably need iTunes 10.1 (at least that's what I understand Apple is saying). Other than for updating to iOS .2, there's no apparent benefit to iTunes 10.1.