I just downloaded several audio files in Safari (some .mp3, some .wav) and found that each time one finished, iTunes would launch on its own and play it. I looked through the Safari and iTunes preferences, and the System Preferences, but couldn't find anything relevant. This is an incredibly annoying behavior - how do I stop it from occurring? I only listen to music using Spotify (and I generally just use QuickLook to preview sound effects)... I only use iTunes to move files between my iMac and iPhone - were it not for that, I'd uninstall iTunes entirely. Also checked Finder preferences. Still nothing. Sending a request to the author of Tinker Tool to see if he could add something that changes this.