iTunes Keeps Randomly Pausing?

What kind of audio setup do you have? I mean output, through an amp or speakers or whatever? I had this problem using a Digi 002 device and found it to be the connecting lead between them was damaged and kept cutting out, forcing itunes to pause.

 

That sounds likely just knowing how the iphone behaves. If one is to unplug the headphones / speakers it will pause... I had faulty headphones once with a short and when I moved them they would lose connection and pause. It was so quick that I wouldn't even hear it when listening.. new headphones and I have never had the issue again.

 

Totally agreed here - check your audio output devices. A loose, damaged, or badly connected cable will definitely cause this issue. Also, it won't hurt to check Activity Monitor while iTunes is playing, to see if there is a system resource issue.