Ever since I installed Leopard (clean install, not an upgrade) I've been experiencing this problem. Everything has been running flawless but after about 6+ days uptime, the mouse will start lagging/jumping like crazy after waking it from sleep. For example, I closed my Macbook Pro screen about an hour ago to head to my parents house and put it in my bag. I get here and open up the screen to wake it up and the mouse is just jumping around like crazy. I waited a few minutes thinking maybe something was loading in the background sucking up all the CPU cycles/resources, but that's not the case. This is about the third time I've seen this problem and it always occurs after waking the computer from sleep with a 5-6+ day uptime. Anyone else experience this issue? This was never a problem in Tiger and I had 30+ day uptimes there.