When I said I had the same setup as robgendreau, that meant the 295.
Yes, it's scanned -- but it's also 561 MB, which is a lot of PDF. There's not the slightest hesitation (I wish I could say that about large images in LR and PS.)
If it's scanned then the Mac isn't having to do as much work redrawing the fonts - it's a simple image resize. Plus if you're using the m295 you probably wouldn't have the issue anyway as the extra power seems to fix the problem.
There are a lots of people with M290X that don-t suffer from this, but also a lot having the issue , I think it's software related
I personally think it's hardware, as 295x users don't seem to have the issue. Do you have links to any reports from 290 users that can handle large .pdf's without any issues?