Keyboard shortcut to enable/disable Spaces?

When at home I use a 30" 2560x1600 display and as you can imagine, it has quite a bit of real estate for windows. So when I'm at home I'd prefer to not use Spaces since it doesn't give me any extra. However, at work I use a 24" 1920x1200 and when on the move I use my Macbook Pro's 1280x800 display and on those Spaces is highly beneficial.

So is there any way to set up a keyboard shortcut to enable or disable Spaces so I don't have to go uncheck Enable Spaces in System Preferences?