I have a large keynote file containing over 70 slides. The file is over 50 MB. I experienced problems opening it earlier; the progress of opening took several minutes in which it seemed to freeze. Yesterday, after adding another large proportion of slides (leading to the file described above), the app was running fine. However, after starting my Mac this morning, the long loading process repeated itself but this time without any result. After several minutes in which the progress bar sticks to about 1/3, a message pops up from keynote simply stating: Can't open file "*filename*.key" I have tried about everything; closing every single application including background applications. Even cleaned up to free HD space (17GB free). I run 2GB RAM. During the opening process I noticed the following in my memory: Wired 206 MB Active 1.2 GB Inactive 610 MB Free 2 MB When running normal it looks more like this: Wired 210 MB Active 900 MB Inactive 90 MB Free 800 MB I run MacOSX 10.6.8 on a 4 year old MacBook. It's not smooth but does the job and I keep the system clean. I'm really desperate for a diagnosis and a solution! Anyone?