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Most 3.5" SATA disks should work, but the gotcha is that the firmware it runs may not support larger disks. Are you trying to replace a failed drive, or re-use the enclosure with 4 new disks?
 
Reuse the enclosure. One of the original drives failed, then I discovered that model had a notoriously high failure rate. So I plan to replace all four.
 
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Reuse the enclosure. One of the original drives failed, then I discovered that model had a notoriously high failure rate. So I plan to replace all four.
Webhead,
Did your replacement drives work? I'm now in the same boat and want to replace all the drives. I hope by keeping the size drive within what was available at the time of manufacture I can keep this enclosure going. Any info from your experience would be helpful. Thanks!
 
Webhead,
Did your replacement drives work? I'm now in the same boat and want to replace all the drives. I hope by keeping the size drive within what was available at the time of manufacture I can keep this enclosure going. Any info from your experience would be helpful. Thanks!

Sorry for the delay!

I've since moved on to a whole new product, but you should be able to replace the drives without problem. I was considering using 4TB units as it's apparently the 3TB ones that have problems.

The 4big enclosures can take up to 16GB or 20GB from memory.
 
Joining in, as I'm having some 4big Quadras, which "require maintenance".
;-)

LaCie's document, WebHead linked to, explicitly mentions the USB 3 modell.
In some other LaCie PDFs I found, the USB 2 modells seem to max out at 16TB in total.

Some thoughts or experiences here?
 
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