System Specs: 2010 Quad-Core 2.8Ghz Mac Pro OSX 10.8.4 24GB RAM 4x2TB Internal drives HighPoint RocketRaid eSata PCIe Card SanDigital 4-bay JBOD eSata Enclosure 4x2TB -> LaCie PCIe USB3.0 Card -> LaCie Porsche Design P’9230 USB3.0 Drive 750GB (used for OS TM backups) First Issue: The USB drive will not mount unless I restart the computer, it does not work as "Plug-n-Play". I dont have another USB3.0 computer but I tested it on my USB2.0 MBP, it mounts perfectly fine on that computer no restart needed. 2nd Issue: My computer runs like crap when the drive it mounted. My mouse sticks and freezes and the system just lags. I dont see any processes killing CPU or memory usage. Once I unmount and turn off the drive, the computer is back to normal. - Only LaCie drives work with their PCIe card, which is lame but thats besides the point. - I spoke to LaCie about the issue and they suggest I take the computer/drive to a repair store to have it checked out? WTF??? - The eSata stuff works flawlessly, however I have not removed the eSata card to see if it's interfering with the USB3.0 card. I may try that tomorrow... Any help is appreciated!