I'm not sure about the latest research however in medical school (I graduated in 2007) I was taught that aniline dyes had previously been associated with bladder cancers. I initially bought the black leather smart case for iPad 2 but returned it when I read on the box that Apple made the cause my using aniline to dye italian leather. I bought the leather case because of the color but I returned I could not get it off my mind. Does anyone else on the boards know anything about aniline dyes? I am sure Apple has done its research but I just could not keep the case knowing what I knew.