It really depends on how I hold it. In my normal holding position, I cant. That's with the right corner in my palm, and the left corner held with my pinky or ring finger. This is the way I can type and also reach the home button. I can reach the edge of the display, but I can't reliably swipe a page because I think the middle of my thumb falls on the screen, so I doesn't register. It's actually easier for me to just double tap the home button and hit the back button. Reachability is very useful for me when I want to use it one handed but also have access to the home button.
I have another way of holding it with it resting on top of my fingertips, but only when I feel safe enough to. This way I can reach most of the screen, but can't reach the home button. And other times I just use two hands. Surprisingly, with all these adjustments I have to make, they weren't hard at all to get used to.