I gotta say, I've read some bad stories surrounding this mouse w/ OSX. I've used many mice with OSX and to much dismay, have never been satisfied. One of my issues with OSX vs. Windows has been mouse tracking. Windows always seemed more precise, regardless of what mouse / software I used. I've used the Mighty Mouse, Bluetooth Apple Mouse, Logitech G7, a cheap Kensington Corded mouse, and now finally, the Logitech VX Revolution. One word: Wow. Most comfortable mouse I've ever used. Better tracking than a G7 gaming grade mouse. Even the clicks are solid and quiet. My hands always get my mice dirty. I've been using this mouse for two weeks and I've yet to get dirt or hand grime on it. I haven't been extra careful, I don't know why it's so clean! I am using Steermouse and a Ratpadz mousepad. Figure I'd share my experience for those looking for a new mouse. 5 out of 5 tails.