Yes. I've been searching the Apple forums and various 2Wire forums for answers awhile now... my setup:
MacBook Pro 15" (latest revision, all updates)
Using AT&T-Uverse with a 2Wire gateway (3700-series)... I've tried changing the wireless channel (after having scanned nearby wireless network channels to make sure there wasn't overlap), changing the wireless protocol (b+g, b only, g only), and changed the order of network adapters used first in Network Preferences and reset the PRAM.
I'll be on the internet when all of a sudden the connection drops (airport icon shows that it's searching for a network), after 30 seconds the connection will resume, then 5 minutes later loses connection again. Rinse and repeat. Sometimes airport won't reconnect on its own (the icon will have exclamation mark) and I'll have to restart the gateway, restart my computer, etc.
I've decided (not determined) that it's due to the 2wire gateway or setup... or something particular about my home wireless network because when I'm at school I have zero problems with my connections through airport. I've basically given up at this point and have made do with the regular outages while at home.