I know what you mean...
I love Lost, and as I was fortunate enough to not haven seen a single episode until I had downloaded Seasons 1 & 2 completely, and I can imagine the extra irritations for those who have seen S1E1 way back when it was first aired: Waiting.
First of all, many questions being asked right at the beginning (the tree swaying monster, polar bears on the island) haven't been answered at all yet, and the irritation grows.
Second, you tend to forget some of the "mysteries' or "questions" you once had, and were dying for to get the answers.
Also, You get intoduced to more characters, and feel lees "involved" with some of them of which you haven't heard of for some time now.
What baffles me is that the cobination of "4, 8, 15, 16, 23, 46" seems less of interest nowadays. When these numbers were first introduced as being really, really significant, the whole web was buzzing about finding any clues available. That was cool.
Now, people seem to tend to have to live with them, until the producers probably give a totally weird and bonckers explanation of them....
I get the feeling more and more of the plot will become "blurred", therefore less striking, and the details become less significant. Remember the logo under that shark? Well, they simply cast that away as an "easter egg". After knowing that, I feel the makers can get away with far more mysteries than the viewer is willing to give away....
Something like a scientific experiment which can "explain it all", however far fetched it may seem.
Something like the following could be a typical explanation of the numbers:
"You, the audience, the viewers, are also part of this experiment. It was our duty to find out how the world would react to such a puzzle. It simply is not a puzzle, but just an experiment to see how all the viewers around the world would react, and find seemingly explanantions and cunning theories to these randomly chosen numbers. Thank you for your cooperation".
The Dharma initiative, aka Lost producers.
EDIT.
Re-reading my post, I understand that the polar bears existance might be slightly explaned: They were brought there for experiments... duh.
But they were free, and other than the fact that the were brought there, nothing satisfying has come up.