The guts of DriveDX, smartmontools,
is open source and free. Someone took that and rewrote it using Apple's own SMART APIs so unless they did something really silly, Apple's API are wonked, or the drive in question doesn't support SMART through the connector smartmontools should work (It may not like USB because I can't get it to give my any information on any drive connected on my 2013 iMac via USB)
Side note, according to alternativeto, there are
8 free alternatives to Drive DX
My rule of thumb is - see if there is a free open source alternative and after gathering information regarding its safety use that that.
That is why I laugh when people about about using MS Office when LibreOffice exists - odds are for what most people want to I does the job and they are throwing away money for the label (reminds me of a PSA done in the Schoolhouse Rock style about someone who gets clothes just for the label and not checking if they fit)