I have a tricked out 2018 Mac Mini and up until recently I was using 3 Asus 32-inch HD monitors (2560x1440), two connected to TB3/USB-C jacks with USB-C to HDMI cables and the third to the HDMI with a straight HDMI cable. I had no problem doing this, they all worked well.
Recently I wanted to add a 4th identical monitor to the mix and bought a Sonnet eGPU from the AppleStore. After a minor hookup issue (Who knew the power cord actually had to be plugged in to make it work?) it all installed just fine and dandy and all 4 monitors worked just fine. The eGPU even installed itself into MacOS and the icon is on the desktop.
I have not noticed any video issues. The only thing I have seen is that one of the monitors tends to have its video slide partly over to the right a minute or two after waking from display sleep or startup, it returns immediatly and does not occur again until the display sleeps or the computer restarts. I don't know if it originates from the monitor or eGPU or even the cable.
I do not do much video editing, most of my work is browser based so I usually have 4 different browsers running in order to keep them clean from cookies affecting our sales commissions. The Mini gets pretty toasty but since I stopped running Parallels the temps and loads are more reasonable.
From what I have read this setup will support 4 4K monitors and if the CFO (aka wife) ever allows it I might spring for some.
I work from home and also have a similarly configured Hades Canyon NUC so as a backup I set it up on the desk on a separate monitor but also arranged things so that if the Mac should fail for some reason I can swap out the eGPU and the USB-3 hub that supports my webcam and mic to the NUC and be up and running again in less than 2 minutes.