Wirelessly posted (Mozilla/5.0 (iPhone; U; CPU iPhone OS 4_1 like Mac OS X; en-us) AppleWebKit/532.9 (KHTML, like Gecko) Version/4.0.5 Mobile/8B117 Safari/6531.22.7)
I had my iTunes content stored on a nas for years with no issues. Obviously wired will provide a more consistent experience than wireless. I've since moved the content back to my iMac, and back up to the nas instead.