It should be pretty easy... I'm still a bit of a novice at OS X Server, but from my understanding, you'd set up a standalone Open Directory server. You'd create your user accounts in WorkGroup Manager. Set up all the properties to map the user homes back to the server etc... Then, bind your Macs to the Open Directory server.
From there, it should just all fall into place... You can manage your Macs and users from the Server.
I know that's lacking a lot of the details on how to accomplish that, but I don't actually have that setup. Just from what I know, that's how I think it would be accomplish. If you Google the individual parts of it, there should be ample documentation on the net.
I hope that helps!