Yes, that is why a Mac Pro with PCIe slots has value for some people, although I am pretty sure that the audio cards could be Thunderbolt connected just fine (as could most of the required HyperDeck cards for video), but it would be much nicer to have them in the machine (and potentially faster). However, I agree with those who have said that RAM upgrades are just not done that often (if ever) in most professional systems, nor are GPU upgrades common. These are done most often by hobbyists or people who are not using these machines for paid work and so do not want to pay for everything up front (or historically, to pay less for the RAM than Apple charged). The speed difference between unified on package RAM and anything in a slot makes it very much a better solution.
If you still need yesterday’s technology, it can easily be connected via Thunderbolt.