Is this a big-drive problem? I say yes
I just got a 1T Samsung SpinPoint F1 which was supposed to be very quiet in terms of vibration but nope, it is not, and it is louder than WD drivers when seeking.
Anyway, I also have a 500GB Seagate drive and a 320GB WD drive installed. These two don't make any audible noises, although the Seagate drive does vibrate MORE than the WD drive. I also have a 500GB WD drive (the original MacPro drive) which vibrates like a dildo.
I gather that the greater the storage the greater the spinning mass (i.e. more platters) which translates to greater vibration should the platters not be perfectly balanced.
I use my MacPro for audio work so I think I am going to go for the following set-up:
System drive: 320GB WD (one platter) for OS and programs
Data drive 1: 320GB WD (one platter) for multitrack audio recording
Data drive 2: 500GB Seagate for all other data (e.g. videos, photos, music...)
But certainly, if you want to be sure that you get drives that don't vibrate, go for 320GB drives because from my experience bigger drives are a lottery.