I haven't tried it on your particular machine, but I have MATLAB 2010a on mine, and it works just fine. Though it feels like it is a bit slower than it's windows counter part when calculation algorithms. Nothing measured, just a feeling of slowness. I had to do a small calculation using the Gauss-Seidel method for my math class, it took 6000 iterations or so, and it takes the computer roughly 10-15 seconds to crunch the numbers, the same program run in windows takes about 5-10 seconds. The rest of the UI is the exact same.
One thing that I haven't gotten to work is the comment shortcut, which is supposed to be cmd-\, it just doesn't work for some reason, I might be doing something wrong but I don't think so.