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I have this exact problem among others.
https://forums.macrumors.com/threads/310858/
You guys are a step above me. I do know my way around a Mac, loyal since I was six. But not into programmer stuff. Any way to dumb it down a bit?? Is re-instillation of OSX an option? Plus I've been unable to update to 10.4.10 yet my modem problems as well confound. My battery problems are quite worriesome as well. Over all........... Plus FedEx botched delivery by two days the first time when I paid for expedited shipping I hate the idea of sending it back. Its my baby!! Any consensus? Back to Apple?

No mice or peripheral devices other than my Samsung. Problem is the same connected or not. I agree it is random, sometimes apps open sometimes not. I've yet to see a pattern.

UPDATE: I did an SMC reset. Closed the lid waited 10mins ... opened it and it awoke fine. Closed it again had dinner tried it again an hour later .. still fine. Closed it and went to bed opened fine this morning. One problem down. I will keep trying sleep/awake through the day see if I can get it to freeze again.
 
There is a checkbox somewhere in the Bluetooth preferences pane that should prevent the mouse from waking the machine from sleep. That should solve your problem. See the article below about mice waking up machines from sleep:

http://docs.info.apple.com/article.html?artnum=301302

I was having this issue and under Bluetooth settings I turned off the "allow Bluetooth devices to wake this computer" and it worked like a charm.

Thanks for the suggestion. It was starting to piss me off.
 
Still having problem

I have tried the smc reset, and am still having the issue. Has anybody tried reinstalling OS X? If so did this work?
 
SR macbook freezen on wake-from-sleep

Hmmm the thing's less than a week old, very frustrating...

I'm there when it wakes up because I'm the one who opens the lid... Each time it's happened I've closed the lid (and I also tried hitting the power button and selecting Sleep from the popup window) and been there to verify that the sleep light starts pulsing... then I walk away...

Then when I come back after more than half an hour or so, the lid is still closed but the light is on solid rather than pulsing... So I open the lid and bam, no mouse clicks and the whole thing goes beachbally in no time...

My new SR macbook does the same thing, or at least mostly the same thing. I haven't been there when the LED switches from throbbing (== good sleep) to solid white (== frozen).

But I get back, open the lid, no mouse cursor, no beach ball, clicks do nothing, keyboard does nothing, screen shows a static image (which may contain what should be momentary visual thingies such as tooltips or mouseovers), the LED is solid white. I have to hold down the power button for an unprepared shutdown.

Most or all of the times this has happened, a corded Microsoft USB mouse has been plugged in. That could be a factor.
 
Similar situation happened to me last night, for the first time. I'm running the latest upgraded MB. I've nothing attached (printer was off) except internet and power. I put it in sleeping mode and went to bed, then in the mid of the night, the machine started waking up automatically and going back to sleep and waking up... loop... It woke me up damn! The only thing I could do is to turn it off. I don't think it froze tho, but I could be wrong coz I was SLEEPING! LOL I'll see if this problem persist...
 
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