You need to manually install a trojan and give it access to system related files and folders via entering your password.
The problem with most malware today is the internet has evolved than plain text like the use of active-x ,Java ,scrip,macro and flash. All these things can be used for good or bad.
No browser is perfect even with a use of a good sanbox and when one goes into setting and disable active-x and tighten up the security.Mostly no one use the bad active-x now days other than very old web sites and Microsoft.
So again even with good sanbox and tighten up the security the malware can makes way on to the system.
When it is on the system it can do any thing you can do that has read or write privileges !!!
DOS ,windows 1x ,windows 2x, windows 3x and windows 9x like windows 95,98,98SE and Me was base on DOS and ran has full admin mode.
Where windows 2000 ,windows XP ,windows vista and windows 7 base on NT the use if user accounts with different level of user read or write privileges.
The problem for home use is most people have only one account that has full read and write privileges.The implementation of UAC in windows vista and windows 7 is joke of security that most time malware slips by UAC .
The sudo and gksu in Unix ,Linux or Mac OS X do is say yap you are a user confirm you authorization .But some one can still slip some malware in that will elevate with your privileges of runing sudo and gksu .And if you only have one account and it is gets malware you are out of luck.
Not say registry errors over the years of computer use.
And now I am lost.
English is not your first language I suppose?
over the years of computer use you can get errors in the registry .That is why some people do back ups and use registry cleaner.