Look at the number of page-in and page-outs: 26 in and 8 out. This is how often the OS has to read data from your disk and put it in main memory. On my 8 gig machine with CS5 + Bridge + Smultron (text editor) + VMWare Fusion + Nightly (Dev build of FF with leaky memory) + Skype (worse resource allocation known to man) + Adium that number is 6 in and 2 out. Meaning I am going to the disk less frequently than you, so my machine is running faster.
Something is eating memory. In your case Chrome. (Chrome is horrible with memory and eats it like its last night at the Vegas buffet)
And another thing, people are right that an SSD will help, a lot. In your case because it is pulling a lot of stuff from the SSD rather than a physical hard drive. But more memory will help since it won't have to ask for stuff from the hard disk as often.
And not running Chrome will help too .. just saying ...