I have a 15" MBPr that I sit on a Targus cooling pad/adjustable angle stand that has USB port replicators (x4) on the back (Never have had any issues with heating though). Through that, I run a USB wireless Logitech trackball mouse and 500gb USB HDD that I use for backups. My 100gb+ iTunes Library is in Apple's iCloud via iTunes Match. I just download playlists and movies that I want at any given time. I originally planned to get a 27" display but decided I don't really need it for my purposes and prefer to just work on the laptop display.
I LOVE my setup! I can easily move around the house or take it with me with no concerns.
I LOVE my setup! I can easily move around the house or take it with me with no concerns.