Take a look (Note: I just closed Excel)
It doesn't look too significant, but if those pageouts all happened at once, you might notice some slowdown.
You can also use "top" in Terminal - it will show the number/sec. For instance:
88012(0) pageins, 1428(0) pageouts, where the number in parenthesis is events per second. If you have it running, while opening and using your apps, you might see if it's a few or many per sec. Again, it's the
rate which will determine whether you will notice a performance hit.
edit: Looking at the Activity Monitor data, it doesn't look significant - the ratio of in vs. out is very small. You have a total of 745MB [essentially] free. Of course, since you've close apps, it's not a good snapshot of your usage.
Also, keep in mind the data in iStat or Activity Monitor is cumulative. If you just booted up and got the pageouts all at once, it's more significant than if the system had been up and running for weeks and the pageouts occurred sporadically.