I do it. I use a Hasselblad 500 c/m that I bought used from Keh with a Canoscan 8600F or something. I hate it. I wish I had the money for a film scanner, but I'm stuck with the flatbed.
The first question for medium format is what format you want to use: 6x4.5, 6x6, 6x7 are the main ones. I prefer shooting square. I never have to worry about turning the camera. And for the most part, I don't crop out of square anyway. 6x7s are heavier, something along the lines of a Mamiya RB67 is nice, but more suited to the studio or on a tripod.