I'm new to this community and hope that you can help me out! I just bought a new iMac with Leopard, and upon hooking up my Alesis io14 interface (which had sortof worked with my G4, albeit with LOTS of latency), i have not been able to get midi working. I've updated to the latest Alesis driver from their website (for Leopard.) My system IS recognizing the Alesis and I THINK i have the correct combination of settings re: Audio IN/OUT in both Garageband AND in the control panel for sound. (I have ALESIS set up as the audio IN and OUT). As for Audio/Midi Setup -- i might have something set incorrectly there, not sure. The whole thing is quite a puzzle, isn't it!!? I can't remember the exact combo that worked on my last setup! PLEASE HELP -- what is going on here???!! The yellow lite on my Alesis, recognizing firewire connection, IS ON...and my midi cables are connected FINE (in to out, out to in) --- i have no idea what to do, and can't make music!!!!