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Is there a way to have multi-users (different passwords, favorites, cookies) in Safari?
If you have been allowing multiple users to share a single account, then you should stop. OS X is designed from the ground up to provide at least one account for each user. Each account can be given privilege levels ranging from Guest to Administrator. Best practices dictate that each administrator should also have a standard account for day-to-day operations. But, I digress.... The bottom line is that there is no reason for users to share accounts with each other.
 
If you have been allowing multiple users to share a single account, then you should stop. OS X is designed from the ground up to provide at least one account for each user. Each account can be given privilege levels ranging from Guest to Administrator.

Agreed. That's what user accounts are for.

Best practices dictate that each administrator should also have a standard account for day-to-day operations.

Nonsense. This has been debunked a myriad of times here. There is zero advantage to running as a standard user over an admin user on a day to day basis. The administrator of the computer should be an admin, most other users should be Standard or Managed users. User accounts are for people, not tasks.

jW
 
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