I am on 10.6.8 with all software updated. I am playing music that I ripped from my CDs to Apple Lossless. I checked Activity Monitor and the CPU activity is low, nothing overly taxing. After hearing a skip, I dragged the playhead back, and on re-play there's no skipping. I don't recall skipping ever occurring when I played music on iTunes before. A bug in the new version of iTunes?