Theres a heck of a lot of stuff going on. I don't know where to look and the layout isnt very clear. Less is more my friend. 🙂
For the header I'd get rid of the box with rounded corners as it serves no purpose and simply adds clutter. I would probably make the logo slightly smaller and left align it and see what it looks like without the reflection.
You also have lines in between the menu buttons on the left that also serve no purpose and make the menu cluttered. If the boxes are separating the buttons, why do you need the lines?
It's the little things (or lack of) that add up to a great design. My advice is get rid of anything that is not essential.
🙂
EDIT: Oh yeh and stick to a maximum of 2 fonts. Use different weights of those fonts for emphasis.