PPC? The MacBooks were the first Intel Macs, meaning they replaced the iBooks, which were PPC.
What made you think MacBooks are PowerPC?
Yes, any 2.5" SATA drive should work without a single catch.
Do not attempt to replace the drive if you have not taken apart laptops for such things before. You will lose screws or place them in the wrong holes. As well you will need to know how to apply thermal paste, and practicing on this laptop is not a great idea.
If you live in the US, I'd be happy to do the swap for free, just pay to ship it. Send me a message if you like. I repair a Mac or two every day, and I take a MacBook down from memory.