Do you mean you want the text to print out sideways on an 8.5 X 11 sheet of paper, with two columns?
You could do that, but you still wouldn't be able to use it to make a book. The pagination wouldn't work correctly (MS Office can't do this either). You could adjust the margins to print one page at a time, then take them to a printer who could set everything up to print properly. You need to go into format -- page -- page, and select "mirror" margins. Is that what you want to do?