If you follow the Apple Support discussions, you would find a mounting body of evidence from a mounting number of service issues that there is something wrong with whatever RAM is being used for the OWC NuRAM 4x4GB (16GB total) installations.
People who are sending it back and getting Hynix and Samsung RAM (even if it is from OWC) are not having the spontaneous shutdowns.
There is other anecdotal evidence that makes it seem possible that stepping down to 12GB solves the problem with NuRAM OWC modules. However, IMHO, not enough people have reported this, yet, to be taken as Gospel. I
do believe that enough people have reported back to take it as Gospel that the cheapest OWC modules called NuRAM are causing a problem when used as 4x4GB.
In my case, I decided not to take any chances, and went from 16 GB of NuRAM down to 12 GB of Samsung and I have not had any more shutdowns.
I have to say that OWC (macsales.com) were very easy to deal with and immediately issued an RMA for the NuRAM and shipped the Samsung memory quickly and without a lot of effort on my part, although I had to eat the $10.70 shipping expense of sending it back to them. You might not even have to pay shipping back, now that there are a couple of long threads at Apple Support talking about how it's rather obviously OWC NuRAM that is causing the biggest problem.
A couple of people responding in the Apple Support threads were Apple employees, and I am thereby certain that it is not a mainboard or firmware problem. It is a RAM problem.
About Crucial: Be careful. Their online automatic configuration routine did not work correctly for me and they sent me RAM that would not even allow my iMac to start. The chip configuration was just wrong, and there's no way around it.
And Crucial compounded the issue by not responding to my request for an RMA for two weeks. From here on, I do not think I will have any reason to buy anything for my Apple products from Crucial.
Bottom line is you can trust OWC, but I would not buy NuRAM from them. Don't be too cheap. Just buy the Samsung to start with, or at least the more expensive OWC brand (not NuRAM), and consider limiting yourself to 12 GB to have the safest configuration on your mission critical machine.
For whatever one dumb old man's opinion is worth.