It depends on how the card draw power.
AFAIK and base on my own test, each 6pins can deliver up to 120W before the cMP shut itself down.
And since apart from the RX480, I never heard any card will intentionally draw more than 75W from the slot, due to that's a widely used standard. So, no matter if there is any self protection on the PCIe slot, I still count that we can only draw 75W from the slot.
So, 120W x2 + 75W = 315W absolute max. But this highly likely will shutdown the Mac at some stage. So, to keep the Mac working, we take 10W away from each 6pin.
Now, 110W x2 + 75W = 295W, this should be the real world operational max.
HOWEVER, this is base on the card can evenly draw the power from each 6pin and get the max 75W from the slot.
In real world, if the card is in 6+8 config. The card may pull power like the following.
50W from PCIe slot
50W from mini 6pin A
120W from mini 6pin B -> 8pin
The total power draw is just 220W, it's even below the official 225W limit. But due to the uneven power draw. It can still shut down the Mac when the 8pin draw 120W from a single 6pin source.
Another way to safely power the card is as follow.
6pin -> 2x SATA (should be 110W limit, but never seen on any official Apple document)
8pin -> 2x mini 6pin (official 150W limit, real world 240W absolute max, operational at 220W max)
PCIe slot (75W).
Technically, this config can power a card that draw up to 335W but still within the official limit. And possible up to 405W operationally.
Anyway, I did post some of my power draw test result at here.
https://forums.macrumors.com/thread...or-approaching-silence.1982499/#post-23120938