I have an odd issue that has developed on my MBP using OS X 10.5.1 Leopard. It only appears to occur when I plug in my External Firewire Lacie Rugged Hard Drive. I only use that Hard Drive approximately once a week when doing a complete mirror backup of my MBP's Hard Drive using SuperDuper. As far as I can tell the issue occurs only once the Hard Drive is plugged in, not because of SuperDuper or the Backup. Here is the issue: For some reason within a minute of plugging in my hard drive my Dock doesn't work. It scrolls when I put the mouse pointer down to the Dock but it won't open up any icons I click on. It's just like it doesn't recognize the left mouse button. Also, I am unable to select any menus at the top of the screen. I can left click on them and even right click on an icon such as Macintosh HD on the desktop and there is no response. I am able to drag Windows across my desktop though but it seems overall that my keyboard becomes inactive. For example in a open Numbers spreadsheet I am able to use the left mouse button (so it works then) to select a textbox and get the blinking cursor but yet if I type and use even the delete key there is no response. Even after I'm done with the Hard Drive if I drag the Lacie to the trash to eject it won't eject. The only way to eject it is simply pull the Firewire cable out. I had a few issues with my system earlier and found out I had some bad memory. The memory was replaced and the problems went away. I am worried I had some corrupted files from that time but what puzzles me is I have used my laptop for weeks with no problems. It is only while I plug in this hard drive. In a worse case if I can't figure out how to fix it I feel I'll have to do a complete format and reinstall Leopard and I don't want to have to do that. This only occurs when I do the backup but can be a pain. Any ideas if I can fix this?