Pull out your opencore drive, your system will boot like a stock system holding down option, but you first have to put in a Mojave drive or older to boot into and a GPU with Mac efi. What are you trying to accomplish by holding down option and booting into a usb drive? if it’s a bootable stick the opencore bootloader will show it on boot. If you’re running OCLP and Ventura You may need a usb 3 hub to see the thumb drive. There is also a new way to flash your bootrom so it works holding option even with Opencore installed and non apple GPUs