I highly doubt that. I really haven't installed anything, nothing that I don't have running on my iMac.
I've installed these apps:
Adium
CandyBar
Shapeshifter
Growl
Application Enhancer (by Unsanity)
Various Unsanity Haxies
Nothing major. Nothing that hasn't worked before. And the problems arose as soon as I had restarted after updating to 10.4.10.
I don't know what your routine is for updating. What I always do if I have custom icons applied or Shapeshifter themes is, save your iContainer, then restore all icons, unload Shapeshifter back to Aqua, and disable it (make sure its unchecked at the main dialog) and unload any other Unsanity apps. Then log out. I always make sure no other app has been running, hence the logging out part of any shapeshifter cache managers. The only thing that should be running of Unsanity apps is APE.
Once all 3rd party stuff is shutdown (growl, quicksilver etc). I pull out the OS package (which is normally combo) from the disk image to the desktop then unmount it and run the package. I don't touch a thing until it asks to be restarted. My procedure is more of a peace of mind thing.
Once thats all done, everything is all rosy peach after several restarts to build up the cache (not the after 2 days part) if you can get in and everything is functioning, load your stuff back up.
Which I let it build up the cache over a period of days. Can't be arsed with constant reboots.

Then put everything back to the way you like it once you know everything is A OK! Which it should be, as the above has always worked for me.
The only reason I have not updated to 10.4.10 is all the complaints about sound popping and the worrying part that people have spoke of, kernel panics since this update. I couldn't be annoyed with the sound popping since I listen to Internet radio everyday.
Application enhancers are not small. These can cause problems if they encounter something that was changed by Apple and they're not ready for it. If I were you, I'd uninstall ShapeShifter and all 3rd party add-ons that are always running.
Tell me something genius... you don't even need to be installing Unsanity stuff to get APE. What makes it worse is, why the hell is Logitech bundling APE with their drivers... I've heard complaints about this too.
To be honest I've never had problems with APE and its been installed for 2 years now. You can still have Shapeshifter installing but not in use, so theres no need to uninstall it.
People that are also getting these problems don't have any haxies. I have also noticed this trend of the first thing theres a problem, the first thing that gets blamed is Unsanity haxies.
So I can clarify, a friend has a Intel iMac and is running 10.4.10 with Unsanity apps which is all working perfectly fine.
I guess it really depends on how or what the user was doing or what they were running during the update process.
Everybody that I've read seems to get some sort of different symptom or another. The two main ones that seems to be hit by the majority is WIFI problems and sound crackling since this update. The WIFI one I've read came into play for a lot was since 10.4.9. Yet it did not affect me. Seems to be lots of gremlins going about.