I am surprised no one else has responded to your enquiry, it is nice to know that you are aware of the limitations of FileVault.
I have been running the trial version of PGP Desktop Professional version 9.9 for the last 29 days and it is about to expire.
Here are my thoughts and experiences using it. My hardware is a Mac Book Pro 2.6GHz (late 2008) with 4GB ram with a 200GB 7200rpm drive and running Mac OS X 10.5.6.
Installation of PGP was a breeze, I encrypted the entire internal hard drive using WDE.
Although some people have commented on other forums that they notice a drop in performance accessing the hard drive when Whole Disk encryption (WDE) is installed. Personally I have not noticed any major difference, theoretically there would be a slight difference, but it has not affected my normal work when using it. I know which option I would prefer security vs. speed.
Even version 9.10 (which was released recently) will not support a Boot Camp dual boot loader. If you have installed Boot Camp previously but no longer use it, it is recommended that you get the Boot Camp Assistant to uninstall any boot loader before installing WDE.
I did have some trouble with Time machine at one stage, where it would not continue to back up to my Time Capsule. I excluded the PGPWDE01 file located in the root directory of my internal drive in the Time Capsule settings and set Time Machine to back up again and all was fine. Remember an encrypted drive will backed up using Time Machine to a Time Capsule in an unencrypted state, if you are backing up to an external drive (and not a TC) your backup I believe (not tested) should be encrypted.
I am still trying to get my head around the using PGP email. The Plug-in for Apples Mail application had to be installed manually, which I thought was a bit naff, I had expected the installer to automatically install this. The installation is documented on their web site.
I have used WDE successfully with Apples Standard and Administrators accounts and even with File Vault accounts with no real problems encountered.
If you decide to purchase a PGP solution, check the licence situation. The difference between a subscription and a perpetual licence.
You will find some of the Mac based documentation hidden away on their web site but a useful place to look for other peoples comments would be their forums.
The PGPs forums are
http://forum.pgp.com/pgp/
Is it worth the money you ask? Well if you want full disk encryption (FDE), I do not believe we have much of a wide choice of software companies to choose from, that are prepared to sell you a commercial version of FDE encryption to a domestic user as compared to the wider choice of free/shareware/commercial software solutions that Windows users have. I would recommend WDE for any laptop user worried about their data, but I am still undecided on purchasing the full blown Desktop Professional package (purely on the price). But then again what price is your data worth to some one else?
I hope this is of some help? I would be interested from others their thoughts and pointers to any other products that offer FDE/WDE.