You could try making an image of the disk and mounting it whenever you play so you don't have to use the CD.
Don't bother, doesn't work with Civ 4. The only legal way to play Civ 4 without inserting the DVD is by using the Steam version.
I agree with getting the Steam version, it's really cheap now. I got Civ IV, Warlords, and Beyond the Sword all for under $40 dollars.
I got Civ IV Complete (that's Civ IV, Warlords, BtS AND Colonization) for 10 euros (about 12 dollars) on Steam during a sale. Works like a charm...
You can run it (I did on a GMA 950-equipped MacBook) but it won't be pretty or quick.
That good.. In your opinion was it worth the money? I only want it if it runs well enough to be enjoyable. i understand it wont be perfect but were you satisfied?