If you're not looking for speed or data security, why not use it in JBOD mode?
[JBOD = Just a Bunch of Disks]
This aggreates all the disks together into one big disk, and can be used with disks of different size - e.g. one 50GB and one 400GB to make a 450GB virtual disk.
That would answer your seeming need to have maximum storage space on a single virtual drive.
Problem then is i think you won't know which data is on which drive. If one drive fails or is removed, it could be the one with the vital files or part of the OS on it.
I think the above posters are right - simply put as much as you can on one disk so it is as full as possible, e.g. OS, long term apps, stuff that doesn't change round much.
Use the other disk for your large files that you're always moving around.
Keep copies of vital folders e.g. mail backup, essays you've written, personal stuff etc on both disks so that if one goes, you've lost nothing irreplaceable.
xoxo
RedTomato