You might be interested in trying Chrome with uBlock Origin + uBlock Origin Extra -formally web socket (2 separate extensions)! - it uses a fraction of the resources of the more common adblockers, and works stupidly well. The advanced options to utilize experimental filters is nice also, as some of them are very useful. It works so well and uses so few resources that you might find yourself using Chrome more than Safari.
I am guessing you already did this, but you may want to run Malwarebytes as well for good measure - there are quite a few adware programs for Mac going around currently that cause annoying popups.