The MacBook Air does not come with a Retina Display, and no, if you have a MacBook Pro with a Retina Display, you cannot turn it off in that way, since the pixels are hardware.
The only thing you can do is using an extra software to use the whole 2560 x 1600 pixel on the 13" MacBook Pro with Retina Display or the whole 2880 x 1800 pixel on the 15" model, but that will make all things quite tiny.
What application do you talk about? Normally the applications not refitted for Retina displays work fine, but a bit blurry, when used on Retina displays, since one pixel by the application will be displayed by four pixels by the display.