It depends on the program. Some apps are completely self contained and can just be drag and dropped over to a new drive. But others, notable MS and Adobe apps, use installers that install support files in other folders... so apps like that cannot just be drag and dropped to a new drive.
Usually a big clue is how the app is installed. If there is an installer that runs to install the app, then that will likely not be a drag and drop move. But if it is an app that just comes inside a DMG file, and you open the DMG and drag/drop to install... that will likely be one you can easily move to another drive.