The Pulse RX 580 is a supported GPU, and the Pulse RX 590 also probably works in cMP from other reports of success that the Nitro RX 590 works. So is it safe to go ahead and get the Pulse RX 590 and that future macOS support will follow if Apple continues to support the RX 580, or are there other hardware differences that might not guarantee this? Are there significant architectural differences between the two? And I know the 590 inches out over the 580 in pixel crunching, so is it worth paying the extra ponie$? I do app dev, design and video work (1080 mostly, but moving to 4K – but not a heavy skilled user), and I like to game a bit if I can get away with it. I’m currently using an R9 380X which is being moved on to my second cMP Hex-core. And one last Q: will the Pulse 590 8GB be Bootcamp Win10Pro compatible? Currently runs perfectly with the R9 380X and can boot backwards and forwards to macOS/Win10.